Tissues Grown in a Petri Dish - Advances in Organoid Techology


A recent issue of Nature (Volume 526(number 7574; October 22, 2015) describes the growth of kidney tissue, a kidney organoid, from human pluripotent stem cells (Taksato, M., Er, P.X., Chiu, H.S., et al., Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis, Nature 526, 564-568, 2015).  In the same issue, Davies presents a synopsis of the article (Davies, J.A., Kidney tissue grown from induced stem cells, Nature  526, 512-513, 2015) for the general scientist.   One of the nice things about Nature is their presentation of information on an important article in suc h a way that it could be understood by a broad spectrum of scientists.   The development of organoids for various tissues not only represents progress toward organ transplantation but also provides a useful system for evaluating drug efficacy and toxicity.   This latter application has the potential of replacing problematic animal testing with a more relevant analytical platform.