Convalescent Serum and Convalescent Plasma and Hyperimmune Globulins


There is use of Ebola survivor plasma to treat newly diagnosed patients.  This is being presented by some as a new concept.  The use of convalescent serum data to at least 1918 with successful use in the treatment of pneumonia (1) and in 1931 (2,3) for measles.  Plasma has replaced serum and has been recently reviewed (4).  Convalescent serum/plasma is a form of a hyperimmune globulin (5).


1.  McGuire, L.W. and Redden, W.R., The use of convalescent human serum in influenza pneumonia-a preliminary report,  Am.J.Pub.Health 8, 741-744, 1918.
2.  Yaughan, H.F. and Bauer, W.W., Public health administration: measles convalescent serum, Am.J.Pub.Health Nations Health 21, 285-286, 1931.
3.  Nabarro, D.N. and Signy, A.G., Convalescent serum in prophylaxis of measles, Br.Med.J. Jan 3, 1(3652), 12-13, 1931
4. Mair-Jenkins, J., Saavedar-Campos, M., Baillie, J.K., et al., Convalescent plasma study group. The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: A systematic review and exploratory meta-analysis,  J.Infect.Dis., in press, 2014.   
5.   Lundblad, R.L., Biotechnology of the Plasma Proteins, Chapter 5,  CRC Press/Taylor and Francis, Boca Raton, Florida,  USA, 2013